Longitudinal analysis of influenza vaccination implicates regulation of RIG-I signaling by DNA methylation

Abstract Influenza virus infection alters the promoter DNA methylation of key immune response-related genes, including type-1 interferons and proinflammatory cytokines. However, less is known about the effect of the influenza vaccine on the epigenome. We utilized a targeted DNA methylation approach...

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Bibliographic Details
Main Authors: Hongxiang Fu, Harry Pickering, Liudmilla Rubbi, Ted M. Ross, Elaine F. Reed, Matteo Pellegrini
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-51665-9