TP63 truncating mutation causes increased cell apoptosis and premature ovarian insufficiency by enhanced transcriptional activation of CLCA2

TP63 truncating mutation causes increased cell apoptosis and premature ovarian insufficiency by enhanced transcriptional activation of CLCA2

Abstract Background Premature ovarian insufficiency (POI) is a severe disorder leading to female infertility. Genetic mutations are important factors causing POI. TP63-truncating mutation has been reported to cause POI by increasing germ cell apoptosis, however what factors mediate this apoptosis re...

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Bibliographic Details
Main Authors: Yali Fan, Shuya Chen, Chunfang Chu, Xiaodan Yin, Jing Jin, Lingyan Zhang, Huihui Yan, Zheng Cao, Ruixia Liu, Mingwei Xin, Lin Li, Chenghong Yin
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Journal of Ovarian Research
Subjects:
Premature ovarian insufficiency
TP63
CLCA2
Apoptosis
Whole-exome sequencing
Online Access:https://doi.org/10.1186/s13048-024-01396-2

Internet

https://doi.org/10.1186/s13048-024-01396-2

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