A New Application of Parallel Synthesis Strategy for Discovery of Amide-Linked Small Molecules as Potent Chondroprotective Agents in TNF-α-Stimulated Chondrocytes.

A New Application of Parallel Synthesis Strategy for Discovery of Amide-Linked Small Molecules as Potent Chondroprotective Agents in TNF-α-Stimulated Chondrocytes.

As part of an effort to profile potential therapeutics for the treatment of inflammation-related diseases, a diversity of amide-linked small molecules was synthesized by using parallel synthesis strategy. Moreover, these new compounds were also evaluated for their inhibitory effects on nitric oxide...

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Bibliographic Details
Main Authors: Chia-Chung Lee, Yang Lo, Ling-Jun Ho, Jenn-Haung Lai, Shiu-Bii Lien, Leou-Chyr Lin, Chun-Liang Chen, Tsung-Chih Chen, Feng-Cheng Liu, Hsu-Shan Huang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4786219?pdf=render

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http://europepmc.org/articles/PMC4786219?pdf=render

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