Different Eukaryotic Initiation Factor 2Bε Mutations Lead to Various Degrees of Intolerance to the Stress of Endoplasmic Reticulum in Oligodendrocytes

Different Eukaryotic Initiation Factor 2Bε Mutations Lead to Various Degrees of Intolerance to the Stress of Endoplasmic Reticulum in Oligodendrocytes

Background: Vanishing white matter disease (VWM), a human autosomal recessive inherited leukoencephalopathy, is due to mutations in eukaryotic initiation factor 2B (eIF2B). eIF2B is responsible for the initiation of protein synthesis by its guanine nucleotide exchange factor (GEF) activity. Mutation...

Full description

Bibliographic Details
Main Authors: Na Chen, Yu-Wu Jiang, Hong-Jun Hao, Ting-Ting Ban, Kai Gao, Zhong-Bin Zhang, Jing-Min Wang, Ye Wu
Format: Article
Language:English
Published: Wolters Kluwer 2015-01-01
Series:Chinese Medical Journal
Subjects:
Autophagy Flux; EIF2B5 (Eukaryotic Initiation Factor 2Bε); Endoplasmic Reticulum Stress; Unfolded Protein Response; Vanishing White Matter Disease
Online Access:http://www.cmj.org/article.asp?issn=0366-6999;year=2015;volume=128;issue=13;spage=1772;epage=1777;aulast=Chen

Internet

http://www.cmj.org/article.asp?issn=0366-6999;year=2015;volume=128;issue=13;spage=1772;epage=1777;aulast=Chen

Similar Items