Novel Prenylated Indole Alkaloids with Neuroprotection on SH-SY5Y Cells against Oxidative Stress Targeting Keap1–Nrf2

Novel Prenylated Indole Alkaloids with Neuroprotection on SH-SY5Y Cells against Oxidative Stress Targeting Keap1–Nrf2

Oxidative stress has been implicated in the etiology of Parkinson’s disease (PD). Molecules non-covalently binding to the Keap1–Nrf2 complex could be a promising therapeutic approach for PD. Herein, two novel prenylated indole alkaloids asperpenazine (<b>1</b>), and asperpendoline (<b...

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Bibliographic Details
Main Authors: Xueyang Xiao, Zhou Tong, Yuexing Zhang, Hui Zhou, Mengying Luo, Tianhui Hu, Ping Hu, Luqi Kong, Zeqin Liu, Chan Yu, Zhiyong Huang, Linzhen Hu
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Marine Drugs
Subjects:
prenylated indole alkaloids
neuroprotection
oxidative stress
Keap1–Nrf2
Online Access:https://www.mdpi.com/1660-3397/20/3/191

Internet

https://www.mdpi.com/1660-3397/20/3/191

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