SIRT2 Deficiency Exacerbates Hepatic Steatosis via a Putative Role of the ER Stress Pathway

SIRT2 Deficiency Exacerbates Hepatic Steatosis via a Putative Role of the ER Stress Pathway

Nonalcoholic fatty liver disease (NAFLD), a condition strongly associated with obesity and insulin resistance, is characterized by hepatic lipid accumulation and activation of the endoplasmic reticulum (ER) stress response. The sirtuin 2 (SIRT2) protein deacetylase is emerging as a new player in met...

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Bibliographic Details
Main Authors: Helena Leal, João Cardoso, Patrícia Valério, Marta Quatorze, Vítor Carmona, Janete Cunha-Santos, Luís Pereira de Almeida, Cláudia Pereira, Cláudia Cavadas, Pedro Gomes
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:International Journal of Molecular Sciences
Subjects:
SIRT2
hepatic steatosis
insulin resistance
ER stress
Online Access:https://www.mdpi.com/1422-0067/23/12/6790

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https://www.mdpi.com/1422-0067/23/12/6790

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