Sphingosine‐1‐phosphate improves outcome of no‐reflow acute myocardial infarction via sphingosine‐1‐phosphate receptor 1

Sphingosine‐1‐phosphate improves outcome of no‐reflow acute myocardial infarction via sphingosine‐1‐phosphate receptor 1

Abstract Aims Therapeutic options targeting post‐ischaemic cardiac remodelling are sparse. The bioactive sphingolipid sphingosine‐1‐phosphate (S1P) reduces ischaemia/reperfusion injury. However, its impact on post‐ischaemic remodelling independently of its infarct size (IS)‐reducing effect is yet un...

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Bibliographic Details
Main Authors: Amin Polzin, Lisa Dannenberg, Marcel Benkhoff, Maike Barcik, Petra Keul, Aysel Ayhan, Sarah Weske, Samantha Ahlbrecht, Kajetan Trojovsky, Carolin Helten, Sebastian Haberkorn, Ulrich Flögel, Tobias Zeus, Tina Müller, Markus H. Gräler, Malte Kelm, Bodo Levkau
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:ESC Heart Failure
Subjects:
Cardioprotection
LAD‐ligation
Infarct size
Remodelling
Sphingosine‐1‐phosphate
Online Access:https://doi.org/10.1002/ehf2.14176

Internet

https://doi.org/10.1002/ehf2.14176

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