3005 Integrin Mac-1 Potentiates Neutrophil Adhesion and NET Release in Antiphospholipid Syndrome

OBJECTIVES/SPECIFIC AIMS: While the role of antiphospholipid antibodies in activating endothelial cells has been extensively studied, the impact of these antibodies on the adhesive potential of leukocytes has received considerably less attention. Mac-1 is a heterodimeric beta-2 integrin primarily ex...

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Bibliographic Details
Main Authors: Gautam Sule, William J. Kelley, Srilakshmi Yalavarthi, Omolola Eniola-Adefeso, Jason S. Knight
Format: Article
Language:English
Published: Cambridge University Press 2019-03-01
Series:Journal of Clinical and Translational Science
Online Access:https://www.cambridge.org/core/product/identifier/S2059866119000360/type/journal_article