Liquid chromatography-mass spectrometry for simultaneous determination of spironolactone and canrenone in plasma samples

Liquid chromatography-mass spectrometry for simultaneous determination of spironolactone and canrenone in plasma samples

Abstract In our study, we aimed to validate a method based on liquid chromatography-mass spectrometry (LC-MS) to quantify spironolactone (SPI) and its active metabolite canrenone (CAN) simultaneously in plasma samples to support in vivo experiments. Compounds were separated by using a C18 column wit...

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Bibliographic Details
Main Authors: Ricardo Ferreira-Nunes, Edson Aliel Teixeira de Almeida, Marcilio Cunha-Filho, Tais Gratieri, Guilherme Martins Gelfuso
Format: Article
Language:English
Published: Universidade de São Paulo 2023-04-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Bioanalytical method
High-performance liquid chromatography
Pharmacokinetics
Antiandrogen
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502023000100323&tlng=en

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502023000100323&tlng=en

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