Liquid chromatography-mass spectrometry for simultaneous determination of spironolactone and canrenone in plasma samples

Liquid chromatography-mass spectrometry for simultaneous determination of spironolactone and canrenone in plasma samples

Abstract In our study, we aimed to validate a method based on liquid chromatography-mass spectrometry (LC-MS) to quantify spironolactone (SPI) and its active metabolite canrenone (CAN) simultaneously in plasma samples to support in vivo experiments. Compounds were separated by using a C18 column wit...

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Bibliographic Details
Main Authors:	Ricardo Ferreira-Nunes, Edson Aliel Teixeira de Almeida, Marcilio Cunha-Filho, Tais Gratieri, Guilherme Martins Gelfuso
Format:	Article
Language:	English
Published:	Universidade de São Paulo 2023-04-01
Series:	Brazilian Journal of Pharmaceutical Sciences
Subjects:	Bioanalytical method High-performance liquid chromatography Pharmacokinetics Antiandrogen
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502023000100323&tlng=en

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