Tumor-suppressive MEG3 induces microRNA-493-5p expression to reduce arabinocytosine chemoresistance of acute myeloid leukemia cells by downregulating the METTL3/MYC axis

Tumor-suppressive MEG3 induces microRNA-493-5p expression to reduce arabinocytosine chemoresistance of acute myeloid leukemia cells by downregulating the METTL3/MYC axis

Abstract Background Chemoresistance serves as a huge obstacle for acute myeloid leukemia (AML) patients. To counteract the chemoresistance in AML cells, we discussed the role of maternally expressed gene 3 (MEG3) in arabinocytosine (AraC) chemoresistance in AML cells. Methods MEG3, microRNA (miR)-49...

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Bibliographic Details
Main Authors: Airong Wang, Yufei Chen, Luyao Shi, Mengya Li, Lingling Li, Shujuan Wang, Chong Wang
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Journal of Translational Medicine
Subjects:
Acute myeloid leukemia
Chemotherapy
Maternally expressed gene 3
microRNA-493-5p
Methyltransferase-like 3
Online Access:https://doi.org/10.1186/s12967-022-03456-x

Internet

https://doi.org/10.1186/s12967-022-03456-x

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