Persistence of KIRneg NK cells after haploidentical hematopoietic stem cell transplantation protects from human cytomegalovirus infection/reactivation

Persistence of KIRneg NK cells after haploidentical hematopoietic stem cell transplantation protects from human cytomegalovirus infection/reactivation

Haploidentical hematopoietic stem cell transplantation (h-HSCT) is a therapeutic option to cure patients affected by hematologic malignancies. The kinetics and the quality of immune-reconstitution (IR) impact the clinical outcome of h-HSCT and limit the onset of life-threatening Human Cytomegaloviru...

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Bibliographic Details
Main Authors: Clara Di Vito, Nicolò Coianiz, Michela Calvi, Sara Terzoli, Elisa Zaghi, Simone Puccio, Alessandro Frigo, Jacopo Mariotti, Chiara De Philippis, Daniele Mannina, Barbara Sarina, Rossana Mineri, Vu Thuy Khanh Le-Trilling, Mirko Trilling, Luca Castagna, Stefania Bramanti, Armando Santoro, Domenico Mavilio
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Immunology
Subjects:
haploidentical hematopoietic stem cell transplantation
natural killer cells
immune reconstitution
human cytomegalovirus
viral immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1266051/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1266051/full

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