Mevalonate Kinase Deficiency and Squalene Synthase Inhibitor (TAK-475): The Balance to Extinguish the Inflammation

Mevalonate Kinase Deficiency and Squalene Synthase Inhibitor (TAK-475): The Balance to Extinguish the Inflammation

Mevalonate Kinase Deficiency (MKD) is a rare inborn disease belonging to the family of periodic fever syndromes. The MKD phenotype is characterized by systemic inflammation involving multiple organs, including the nervous system. Current anti-inflammatory approaches to MKD are only partially effecti...

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Váldodahkkit: Erika Rimondi, Erica Valencic, Alberto Tommasini, Paola Secchiero, Elisabetta Melloni, Annalisa Marcuzzi
Materiálatiipa: Artihkal
Giella:English
Almmustuhtton: MDPI AG 2021-09-01
Ráidu:Biomolecules
Fáttát:
mevalonate
inflammation
drug repositioning
rare disease
Liŋkkat:https://www.mdpi.com/2218-273X/11/10/1438

Interneahtta

https://www.mdpi.com/2218-273X/11/10/1438

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