Saikosaponin D alleviates inflammatory response of osteoarthritis and mediates autophagy via elevating microRNA-199-3p to target transcription Factor-4

Saikosaponin D alleviates inflammatory response of osteoarthritis and mediates autophagy via elevating microRNA-199-3p to target transcription Factor-4

Abstract Objective This study was to investigate the underlying mechanism by which Saikosaponin D (SSD) mitigates the inflammatory response associated with osteoarthritis (OA) and regulates autophagy through upregulation of microRNA (miR)-199-3p and downregulation of transcription Factor-4 (TCF4). M...

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Bibliographic Details
Main Authors: Ming Yan, DaWei Zhang, Min Yang
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Osteoarthritis
Saikosaponin D
MicroRNA-42
Transcription Factor-4
Autophagy
Online Access:https://doi.org/10.1186/s13018-024-04607-0

Internet

https://doi.org/10.1186/s13018-024-04607-0

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