Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development

Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development

The gene regulatory networks that coordinate the development of the cardiac and pulmonary systems are essential for terrestrial life but poorly understood. The T-box transcription factor Tbx5 is critical for both pulmonary specification and heart development, but how these activities are mechanistic...

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Bibliographic Details
Main Authors: Scott A Rankin, Jeffrey D Steimle, Xinan H Yang, Ariel B Rydeen, Kunal Agarwal, Praneet Chaturvedi, Kohta Ikegami, Michael J Herriges, Ivan P Moskowitz, Aaron M Zorn
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-10-01
Series:eLife
Subjects:
Xenopus
retinoic acid
cardiopulmonary
lung development
Tbx5 transcription factor
mouse
Online Access:https://elifesciences.org/articles/69288

Internet

https://elifesciences.org/articles/69288

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