Tight Chk1 Levels Control Replication Cluster Activation in Xenopus.

Tight Chk1 Levels Control Replication Cluster Activation in Xenopus.

DNA replication in higher eukaryotes initiates at thousands of origins according to a spatio-temporal program. The ATR/Chk1 dependent replication checkpoint inhibits the activation of later firing origins. In the Xenopus in vitro system initiations are not sequence dependent and 2-5 origins are grou...

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Bibliographic Details
Main Authors: Marie Platel, Arach Goldar, Jennifer M Wiggins, Pedro Barbosa, Pierre Libeau, Pierre Priam, Hemalatha Narassimprakash, Xenia Grodzenski, Kathrin Marheineke
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4457610?pdf=render

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http://europepmc.org/articles/PMC4457610?pdf=render

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