Sevoflurane Increases Hippocampal Theta Oscillations and Impairs Memory Via TASK-3 Channels
Sevoflurane can induce memory impairment during clinical anesthesia; however, the underlying mechanisms are largely unknown. TASK-3 channels are one of the potential targets of sevoflurane. Accumulating evidence supports a negative role of intracranial theta rhythms (4–12 Hz) in memory formation. He...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.728300/full |
| _version_ | 1819121303424073728 |
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| author | Linlin Han Shuai Zhao Feng Xu Yafeng Wang Ruihui Zhou Shiqian Huang Yuanyuan Ding Daling Deng Weike Mao Xiangdong Chen |
| author_facet | Linlin Han Shuai Zhao Feng Xu Yafeng Wang Ruihui Zhou Shiqian Huang Yuanyuan Ding Daling Deng Weike Mao Xiangdong Chen |
| author_sort | Linlin Han |
| collection | DOAJ |
| description | Sevoflurane can induce memory impairment during clinical anesthesia; however, the underlying mechanisms are largely unknown. TASK-3 channels are one of the potential targets of sevoflurane. Accumulating evidence supports a negative role of intracranial theta rhythms (4–12 Hz) in memory formation. Here, we investigated whether TASK-3 channels contribute to sevoflurane-induced memory impairment by regulating hippocampal theta rhythms. In this study, the memory performance of mice was tested by contextual fear conditioning and inhibitory avoidance experiments. The hippocampal local field potentials (LFPs) were recorded from chronically implanted electrodes located in CA3 region. The results showed that sevoflurane concentration-dependently impaired the memory function of mice, as evidenced by the decreased time mice spent on freezing and reduced latencies for mice to enter the shock compartment. Our electrophysiological results revealed that sevoflurane also enhanced the spectral power of hippocampal LFPs (1–30 Hz), particularly in memory-related theta rhythms (4–12 Hz). These effects were mitigated by viral-mediated knockdown of TASK-3 channels in the hippocampal CA3 region. The knockdown of hippocampal TASK-3 channels significantly reduced the enhancing effect of sevoflurane on hippocampal theta rhythms and alleviated sevoflurane-induced memory impairment. Our data indicate that sevoflurane can increase hippocampal theta oscillations and impair memory function via TASK-3 channels. |
| first_indexed | 2024-12-22T06:34:25Z |
| format | Article |
| id | doaj.art-ff286772a91b4f0aacd8f3ece73fef17 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-22T06:34:25Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-ff286772a91b4f0aacd8f3ece73fef172022-12-21T18:35:38ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-10-011210.3389/fphar.2021.728300728300Sevoflurane Increases Hippocampal Theta Oscillations and Impairs Memory Via TASK-3 ChannelsLinlin HanShuai ZhaoFeng XuYafeng WangRuihui ZhouShiqian HuangYuanyuan DingDaling DengWeike MaoXiangdong ChenSevoflurane can induce memory impairment during clinical anesthesia; however, the underlying mechanisms are largely unknown. TASK-3 channels are one of the potential targets of sevoflurane. Accumulating evidence supports a negative role of intracranial theta rhythms (4–12 Hz) in memory formation. Here, we investigated whether TASK-3 channels contribute to sevoflurane-induced memory impairment by regulating hippocampal theta rhythms. In this study, the memory performance of mice was tested by contextual fear conditioning and inhibitory avoidance experiments. The hippocampal local field potentials (LFPs) were recorded from chronically implanted electrodes located in CA3 region. The results showed that sevoflurane concentration-dependently impaired the memory function of mice, as evidenced by the decreased time mice spent on freezing and reduced latencies for mice to enter the shock compartment. Our electrophysiological results revealed that sevoflurane also enhanced the spectral power of hippocampal LFPs (1–30 Hz), particularly in memory-related theta rhythms (4–12 Hz). These effects were mitigated by viral-mediated knockdown of TASK-3 channels in the hippocampal CA3 region. The knockdown of hippocampal TASK-3 channels significantly reduced the enhancing effect of sevoflurane on hippocampal theta rhythms and alleviated sevoflurane-induced memory impairment. Our data indicate that sevoflurane can increase hippocampal theta oscillations and impair memory function via TASK-3 channels.https://www.frontiersin.org/articles/10.3389/fphar.2021.728300/fulllocal field potentialsmemorysevofluraneTASK-3 channelstheta rhythms |
| spellingShingle | Linlin Han Shuai Zhao Feng Xu Yafeng Wang Ruihui Zhou Shiqian Huang Yuanyuan Ding Daling Deng Weike Mao Xiangdong Chen Sevoflurane Increases Hippocampal Theta Oscillations and Impairs Memory Via TASK-3 Channels Frontiers in Pharmacology local field potentials memory sevoflurane TASK-3 channels theta rhythms |
| title | Sevoflurane Increases Hippocampal Theta Oscillations and Impairs Memory Via TASK-3 Channels |
| title_full | Sevoflurane Increases Hippocampal Theta Oscillations and Impairs Memory Via TASK-3 Channels |
| title_fullStr | Sevoflurane Increases Hippocampal Theta Oscillations and Impairs Memory Via TASK-3 Channels |
| title_full_unstemmed | Sevoflurane Increases Hippocampal Theta Oscillations and Impairs Memory Via TASK-3 Channels |
| title_short | Sevoflurane Increases Hippocampal Theta Oscillations and Impairs Memory Via TASK-3 Channels |
| title_sort | sevoflurane increases hippocampal theta oscillations and impairs memory via task 3 channels |
| topic | local field potentials memory sevoflurane TASK-3 channels theta rhythms |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.728300/full |
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