Identification of a Class of WNK Isoform-Specific Inhibitors Through High-Throughput Screening

Identification of a Class of WNK Isoform-Specific Inhibitors Through High-Throughput Screening

Julita Chlebowicz,1 Radha Akella,1 John M Humphreys,1 Haixia He,1 Ashari R Kannangara,1 Shuguang Wei,2 Bruce Posner,2 Elizabeth J Goldsmith1 1Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX, USA; 2Department of Biochemistry, The University of Texas Southwest...

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Bibliographic Details
Main Authors: Chlebowicz J, Akella R, Humphreys JM, He H, Kannangara AR, Wei S, Posner B, Goldsmith EJ
Format: Article
Language:English
Published: Dove Medical Press 2023-01-01
Series:Drug Design, Development and Therapy
Subjects:
wnk
inhibition screen
kinase inhibitor
wnk3-specific
structure activity relationship
crystallography
Online Access:https://www.dovepress.com/identification-of-a-class-of-wnk-isoform-specific-inhibitors-through-h-peer-reviewed-fulltext-article-DDDT

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https://www.dovepress.com/identification-of-a-class-of-wnk-isoform-specific-inhibitors-through-h-peer-reviewed-fulltext-article-DDDT

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