Proline-rich tyrosine kinase 2 (Pyk2) promotes cell motility of hepatocellular carcinoma through induction of epithelial to mesenchymal transition.

Proline-rich tyrosine kinase 2 (Pyk2) promotes cell motility of hepatocellular carcinoma through induction of epithelial to mesenchymal transition.

AIMS: Proline-rich tyrosine kinase 2 (Pyk2), a non-receptor tyrosine kinase of the focal adhesion kinase (FAK) family, is up-regulated in more than 60% of the tumors of hepatocellular carcinoma (HCC) patients. Forced overexpression of Pyk2 can promote the proliferation and invasion of HCC cells. In...

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Bibliographic Details
Main Authors: Chris K Sun, Kevin T Ng, Zophia X Lim, Qiao Cheng, Chung Mau Lo, Ronnie T Poon, Kwan Man, Nathalie Wong, Sheung Tat Fan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3080371?pdf=render

Internet

http://europepmc.org/articles/PMC3080371?pdf=render

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