Population-specific positive selection on low CR1 expression in malaria-endemic regions.

Population-specific positive selection on low CR1 expression in malaria-endemic regions.

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Complement Receptor Type 1 (CR1) is a malaria-associated gene that encodes a transmembrane receptor of erythrocytes and is crucial for malaria parasite invasion. The expression of CR1 contributes to the rosetting of erythrocytes in the brain bloodstream, causing cerebral malaria, the most severe for...

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Bibliographic Details
Main Authors: Paolo Alberto Lorenzini, Elena S Gusareva, Amit Gourav Ghosh, Nurul Adilah Binte Ramli, Peter Rainer Preiser, Hie Lim Kim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0280282

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https://doi.org/10.1371/journal.pone.0280282

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