Structural and functional prediction, evaluation, and validation in the post-sequencing era

Structural and functional prediction, evaluation, and validation in the post-sequencing era

The surge of genome sequencing data has underlined substantial genetic variants of uncertain significance (VUS). The decryption of VUS discovered by sequencing poses a major challenge in the post-sequencing era. Although experimental assays have progressed in classifying VUS, only a tiny fraction of...

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Bibliographic Details
Main Authors: Chang Li, Yixuan Luo, Yibo Xie, Zaifeng Zhang, Ye Liu, Lihui Zou, Fei Xiao
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Missense variants
Artificial intelligence
Protein structure
Post-sequencing era
Clinical interpretation
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037023005056

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http://www.sciencedirect.com/science/article/pii/S2001037023005056

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