Homer 1 gene products orchestrate Ca2+-permeable AMPA receptor distribution and LTP expression

We studied the role of Homer1 gene products on the presence of synaptic Ca2+-permeable AMPA receptors (AMPARs) and LTP generation in hippocampal CA1 pyramidal neurons, using mice that either lacked all Homer1 isoforms (Homer1 KO) or overexpressed the immediate early gene product Homer1a (H1aTG). We...

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Bibliographic Details
Main Authors: Andrei eRozov, Aleksandar eZivkovic, Martin K Schwarz
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-09-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnsyn.2012.00004/full