Drosophila Mpv17 forms an ion channel and regulates energy metabolism

Drosophila Mpv17 forms an ion channel and regulates energy metabolism

Summary: Mutations in MPV17 are a major contributor to mitochondrial DNA (mtDNA) depletion syndromes, a group of inherited genetic conditions due to mtDNA instability. To investigate the role of MPV17 in mtDNA maintenance, we generated and characterized a Drosophila melanogaster Mpv17 (dMpv17) KO mo...

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Bibliographic Details
Main Authors: Samantha Corrà, Vanessa Checchetto, Michele Brischigliaro, Chiara Rampazzo, Emanuela Bottani, Cristina Gagliani, Katia Cortese, Cristiano De Pittà, Marco Roverso, Diego De Stefani, Sara Bogialli, Massimo Zeviani, Carlo Viscomi, Ildiko Szabò, Rodolfo Costa
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:iScience
Subjects:
model organism
molecular biology
physiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223020321

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http://www.sciencedirect.com/science/article/pii/S2589004223020321

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