Cholecystokinin type B receptor-mediated inhibition of A-type K+ channels enhances sensory neuronal excitability through the phosphatidylinositol 3-kinase and c-Src-dependent JNK pathway

Cholecystokinin type B receptor-mediated inhibition of A-type K+ channels enhances sensory neuronal excitability through the phosphatidylinositol 3-kinase and c-Src-dependent JNK pathway

Abstract Background Cholecystokinin (CCK) is implicated in the regulation of nociceptive sensitivity of primary afferent neurons. Nevertheless, the underlying cellular and molecular mechanisms remain unknown. Methods Using patch clamp recording, western blot analysis, immunofluorescent labelling, en...

Full description

Bibliographic Details
Main Authors: Shumin Yu, Yuan Zhang, Xianyang Zhao, Zhigang Chang, Yuan Wei, Yufang Sun, Dongsheng Jiang, Xinghong Jiang, Jin Tao
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Cell Communication and Signaling
Subjects:
Cholecystokinin
A-type K+ channel
Dorsal root ganglion
Neuronal excitability
Online Access:http://link.springer.com/article/10.1186/s12964-019-0385-8

Internet

http://link.springer.com/article/10.1186/s12964-019-0385-8

Similar Items