A single-dose MCMV-based vaccine elicits long-lasting immune protection in mice against distinct SARS-CoV-2 variants

A single-dose MCMV-based vaccine elicits long-lasting immune protection in mice against distinct SARS-CoV-2 variants

Current vaccines against COVID-19 elicit immune responses that are overall strong but wane rapidly. As a consequence, the necessary booster shots have contributed to vaccine fatigue. Hence, vaccines that would provide lasting protection against COVID-19 are needed, but are still unavailable. Cytomeg...

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Bibliographic Details
Main Authors: Kristin Metzdorf, Henning Jacobsen, Yeonsu Kim, Luiz Gustavo Teixeira Alves, Upasana Kulkarni, Maja Cokarić Brdovčak, Jelena Materljan, Kathrin Eschke, M. Zeeshan Chaudhry, Markus Hoffmann, Federico Bertoglio, Maximilian Ruschig, Michael Hust, Marko Šustić, Astrid Krmpotić, Stipan Jonjić, Marek Widera, Sandra Ciesek, Stefan Pöhlmann, Markus Landthaler, Luka Čičin-Šain
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-07-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
COVID-19
MCMV
vaccination
single-dose
long-lasting protection
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1383086/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1383086/full

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