Miniaturized microscope for non-invasive imaging of leukocyte-endothelial interaction in human microcirculation

Abstract We present a miniature oblique back-illumination microscope (mOBM) for imaging the microcirculation of human oral mucosa, enabling real-time, label-free phase contrast imaging of individual leukocytes circulating in the bloodstream, as well as their rolling and adhesion on vascular walls—th...

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Bibliographic Details
Main Authors: Arutyun Bagramyan, Charles P. Lin
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-45018-1