Homologous recombination deficiency is inversely correlated with microsatellite instability and identifies immunologically cold tumors in most cancer types

Homologous recombination deficiency is inversely correlated with microsatellite instability and identifies immunologically cold tumors in most cancer types

Abstract Homologous recombination deficiency (HRD) leads to DNA double‐strand breaks and can be exploited by the use of poly (ADP‐ribose) polymerase (PARP) inhibitors to induce synthetic lethality. Extending the original therapeutic concept, the role of HRD is currently being investigated in clinica...

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Bibliographic Details
Main Authors: Jan Budczies, Klaus Kluck, Susanne Beck, Iordanis Ourailidis, Michael Allgäuer, Michael Menzel, Daniel Kazdal, Lukas Perkhofer, Alexander Kleger, Peter Schirmacher, Thomas Seufferlein, Albrecht Stenzinger
Format: Article
Language:English
Published: Wiley 2022-07-01
Series:The Journal of Pathology: Clinical Research
Subjects:
homologous recombination deficiency
HRD
microsatellite instability
MSI
PARP inhibitors
immune cell populations
Online Access:https://doi.org/10.1002/cjp2.271

Internet

https://doi.org/10.1002/cjp2.271

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