Bone Morphogenetic Protein (BMP)4 But Not BMP2 Disrupts the Barrier Integrity of Retinal Pigment Epithelia and Induces Their Migration: A Potential Role in Neovascular Age-Related Macular Degeneration

Bone Morphogenetic Protein (BMP)4 But Not BMP2 Disrupts the Barrier Integrity of Retinal Pigment Epithelia and Induces Their Migration: A Potential Role in Neovascular Age-Related Macular Degeneration

Disruption of retinal pigment epithelial (RPE) barrier integrity and RPE migration are hallmark features in neovascular age-related macular degeneration (nAMD), but the underlying causes and pathophysiology are not completely well-defined. Herein, we aimed to evaluate the effect of bone morphogeneti...

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Bibliographic Details
Main Authors: Ahmed S. Ibrahim, Khaled Hussein, Fang Wang, Ming Wan, Nancy Saad, Maamon Essa, Ivana Kim, Akbar Shakoor, Leah A. Owen, Margaret M. DeAngelis, Mohamed Al-Shabrawey
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Journal of Clinical Medicine
Subjects:
age related macular degeneration (AMD)
BMP4
BMP2
retinal pigment epithelial cells (RPE)
ARPE-19
Online Access:https://www.mdpi.com/2077-0383/9/7/2293

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https://www.mdpi.com/2077-0383/9/7/2293

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