Neurofilament light chain and dorsal root ganglia injury after adeno-associated virus 9 gene therapy in nonhuman primates

Neurofilament light chain and dorsal root ganglia injury after adeno-associated virus 9 gene therapy in nonhuman primates

In nonhuman primates (NHPs), adeno-associated virus serotype 9 (AAV9) vectorized gene therapy can cause asymptomatic microscopic injury to dorsal root ganglia (DRG) and trigeminal ganglia (TG) somatosensory neurons, causing neurofilament light chain (NfL) to diffuse into cerebrospinal fluid (CSF) an...

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Bibliographic Details
Main Authors: Eric W. Johnson, Jeffrey J. Sutherland, Emily Meseck, Cameron McElroy, Deepa H. Chand, Francis Fonyuy Tukov, Eloise Hudry, Kelley Penraat
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
adeno-associated virus 9 gene therapy
cerebrospinal fluid
dorsal root ganglia/trigeminal ganglia pathology
dorsal root ganglia toxicity
nonclinical toxicology
neurofilament light chain
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050122001851

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http://www.sciencedirect.com/science/article/pii/S2329050122001851

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