Loss of the Coffin-Lowry syndrome-associated gene RSK2 alters ERK activity, synaptic function and axonal transport in Drosophila motoneurons

Loss of the Coffin-Lowry syndrome-associated gene RSK2 alters ERK activity, synaptic function and axonal transport in Drosophila motoneurons

Plastic changes in synaptic properties are considered as fundamental for adaptive behaviors. Extracellular-signal-regulated kinase (ERK)-mediated signaling has been implicated in regulation of synaptic plasticity. Ribosomal S6 kinase 2 (RSK2) acts as a regulator and downstream effector of ERK. In th...

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Bibliographic Details
Main Authors: Katherina Beck, Nadine Ehmann, Till F. M. Andlauer, Dmitrij Ljaschenko, Katrin Strecker, Matthias Fischer, Robert J. Kittel, Thomas Raabe
Format: Article
Language:English
Published: The Company of Biologists 2015-11-01
Series:Disease Models & Mechanisms
Subjects:
Drosophila
Motoneuron
Neuromuscular junction
RSK
MAPK signaling
Synapse
Axonal transport
Online Access:http://dmm.biologists.org/content/8/11/1389

Internet

http://dmm.biologists.org/content/8/11/1389

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