CXCL12 mediates trophic interactions between endothelial and tumor cells in glioblastoma.

CXCL12 mediates trophic interactions between endothelial and tumor cells in glioblastoma.

Emerging evidence suggests endothelial cells (EC) play a critical role in promoting Glioblastoma multiforme (GBM) cell proliferation and resistance to therapy. The molecular basis for GBM-EC interactions is incompletely understood. We hypothesized that the chemokine CXCL12 and its receptor CXCR4 cou...

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Bibliographic Details
Main Authors: Shyam Rao, Rajarshi Sengupta, Eun Joo Choe, B Mark Woerner, Erin Jackson, Tao Sun, Jeffrey Leonard, David Piwnica-Worms, Joshua B Rubin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3299723?pdf=render

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http://europepmc.org/articles/PMC3299723?pdf=render

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