Neuronal maturation reduces the type I IFN response to orthobunyavirus infection and leads to increased apoptosis of human neurons

Neuronal maturation reduces the type I IFN response to orthobunyavirus infection and leads to increased apoptosis of human neurons

Abstract Background La Crosse virus (LACV) is the leading cause of pediatric arboviral encephalitis in the USA. LACV encephalitis can result in learning and memory deficits, which may be due to infection and apoptosis of neurons in the brain. Despite neurons being the primary cell infected in the br...

Full description

Bibliographic Details
Main Authors: Clayton W. Winkler, Tyson A. Woods, Bradley R. Groveman, Aaron B. Carmody, Emily E. Speranza, Craig A. Martens, Sonja M. Best, Cathryn L. Haigh, Karin E. Peterson
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Journal of Neuroinflammation
Subjects:
Orthobunyavirus
Encephalitis
Human cerebral organoids
Neurogenesis
Neuron
Type I interferon
Online Access:http://link.springer.com/article/10.1186/s12974-019-1614-1

Internet

http://link.springer.com/article/10.1186/s12974-019-1614-1

Similar Items