An EPAC1/PDE1C-Signaling Axis Regulates Formation of Leading-Edge Protrusion in Polarized Human Arterial Vascular Smooth Muscle Cells

An EPAC1/PDE1C-Signaling Axis Regulates Formation of Leading-Edge Protrusion in Polarized Human Arterial Vascular Smooth Muscle Cells

Pharmacological activation of protein kinase A (PKA) reduces migration of arterial smooth muscle cells (ASMCs), including those isolated from human arteries (HASMCs). However, when individual migration-associated cellular events, including the polarization of cells in the direction of movement or re...

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Bibliographic Details
Main Authors: Paulina Brzezinska, Donald H. Maurice
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Cells
Subjects:
exchange protein activated by camp
epac1
cyclic nucleotide phosphodiesterase
pde1c
human arterial smooth muscle cells
hasmcs
migration
leading edge protrusion
camp
chemotaxis
Online Access:https://www.mdpi.com/2073-4409/8/12/1473

Internet

https://www.mdpi.com/2073-4409/8/12/1473

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