Combinations of Histone Deacetylase Inhibitors with Distinct Latency Reversing Agents Variably Affect HIV Reactivation and Susceptibility to NK Cell-Mediated Killing of T Cells That Exit Viral Latency

Combinations of Histone Deacetylase Inhibitors with Distinct Latency Reversing Agents Variably Affect HIV Reactivation and Susceptibility to NK Cell-Mediated Killing of T Cells That Exit Viral Latency

The ‘shock-and-kill’ strategy to purge the latent HIV reservoir relies on latency-reversing agents (LRAs) to reactivate the provirus and subsequent immune-mediated killing of HIV-expressing cells. Yet, clinical trials employing histone deacetylase inhibitors (HDACis; Vorinostat, Romidepsin, Panobino...

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Bibliographic Details
Main Authors: Daniela A. Covino, Maria G. Desimio, Margherita Doria
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
HIV-1 cure
shock-and-kill
latency reversing agents
histone deacetylase inhibitor
PKC agonist
proteasome inhibitor
Online Access:https://www.mdpi.com/1422-0067/22/13/6654

Internet

https://www.mdpi.com/1422-0067/22/13/6654

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