Endothelin‐1 Drives Epithelial‐Mesenchymal Transition in Hypertensive Nephroangiosclerosis

Endothelin‐1 Drives Epithelial‐Mesenchymal Transition in Hypertensive Nephroangiosclerosis

BackgroundTubulointerstitial fibrosis, the final outcome of most kidney diseases, involves activation of epithelial mesenchymal transition (EMT). Endothelin‐1 (ET‐1) activates EMT in cancer cells, but it is not known whether it drives EMT in the kidney. We therefore tested the hypothesis that tubulo...

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Bibliographic Details
Main Authors: Teresa M. Seccia, Brasilina Caroccia, Francesca Gioco, Maria Piazza, Valentina Buccella, Diego Guidolin, Eugenia Guerzoni, Barbara Montini, Lucia Petrelli, Elisa Pagnin, Verdiana Ravarotto, Anna S. Belloni, Lorenzo A. Calò, Gian Paolo Rossi
Format: Article
Language:English
Published: Wiley 2016-07-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
endothelin‐1
epithelial to mesenchymal transition
fibrosis
hypertension
kidney
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.116.003888

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.116.003888

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