Histone lysine methacrylation is a dynamic post-translational modification regulated by HAT1 and SIRT2

Histone lysine methacrylation is a dynamic post-translational modification regulated by HAT1 and SIRT2

Abstract Histone lysine crotonylation is a posttranslational modification with demonstrated functions in transcriptional regulation. Here we report the discovery of a new type of histone posttranslational modification, lysine methacrylation (Kmea), corresponding to a structural isomer of crotonyllys...

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Bibliographic Details
Main Authors: Kyle Delaney, Minjia Tan, Zhesi Zhu, Jinjun Gao, Lunzhi Dai, Sunjoo Kim, Jun Ding, Maomao He, Levon Halabelian, Lu Yang, Prabakaran Nagarajan, Mark Robert Parthun, Sangkyu Lee, Saadi Khochbin, Yujun George Zheng, Yingming Zhao
Format: Article
Language:English
Published: Nature Publishing Group 2021-12-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-021-00344-4

Internet

https://doi.org/10.1038/s41421-021-00344-4

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