Substrate Affinity Is Not Crucial for Therapeutic L-Asparaginases: Antileukemic Activity of Novel Bacterial Enzymes

Substrate Affinity Is Not Crucial for Therapeutic L-Asparaginases: Antileukemic Activity of Novel Bacterial Enzymes

L-asparaginases are used in the treatment of acute lymphoblastic leukemia. The aim of this work was to compare the antiproliferative potential and proapoptotic properties of novel L-asparaginases from different structural classes, viz. EcAIII and KpAIII (class 2), as well as ReAIV and ReAV (class 3)...

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Bibliographic Details
Main Authors: Anna Ściuk, Kinga Wątor, Izabela Staroń, Paulina Worsztynowicz, Kinga Pokrywka, Joanna Sliwiak, Marta Kilichowska, Kamila Pietruszewska, Zofia Mazurek, Anna Skalniak, Krzysztof Lewandowski, Mariusz Jaskolski, Joanna I. Loch, Marcin Surmiak
Format: Article
Language:English
Published: MDPI AG 2024-05-01
Series:Molecules
Subjects:
L-asparaginase
substrate affinity
leukemia
cell proliferation
cell apoptosis
Online Access:https://www.mdpi.com/1420-3049/29/10/2272

Internet

https://www.mdpi.com/1420-3049/29/10/2272

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