Quantitative modeling of human liver reveals dysregulation of glycosphingolipid pathways in nonalcoholic fatty liver disease

Quantitative modeling of human liver reveals dysregulation of glycosphingolipid pathways in nonalcoholic fatty liver disease

Summary: Nonalcoholic fatty liver disease (NAFLD) is an increasingly prevalent disease that is associated with multiple metabolic disturbances, yet the metabolic pathways underlying its progression are poorly understood. Here, we studied metabolic pathways of the human liver across the full histolog...

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Bibliographic Details
Main Authors: Partho Sen, Olivier Govaere, Tim Sinioja, Aidan McGlinchey, Dawei Geng, Vlad Ratziu, Elisabetta Bugianesi, Jörn M. Schattenberg, Antonio Vidal-Puig, Michael Allison, Simon Cockell, Ann K. Daly, Tuulia Hyötyläinen, Quentin M. Anstee, Matej Orešič
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:iScience
Subjects:
Health sciences
Systems biology
Omics
Metabolomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222012214

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http://www.sciencedirect.com/science/article/pii/S2589004222012214

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