Molecular Mechanisms that Regulate Epidermal Growth Factor Receptor Inactivation

The Epidermal Growth Factor Receptor (EGFR) is the prototypical receptor tyrosine kinase (RTK). These cell surface receptors are integral membrane proteins that bind ligands on their extracellular domain and relay that information to within the cell. The activated EGFR regulates diverse cell fates s...

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Bibliographic Details
Main Authors: Brian P. Ceresa, Phillip A. Vanlandingham
Format: Article
Language:English
Published: SAGE Publishing 2008-01-01
Series:Clinical Medicine Insights: Oncology
Online Access:https://doi.org/10.4137/CMO.S498