Conserved Motifs within Hepatitis C Virus Envelope (E2) RNA and Protein Independently Inhibit T Cell Activation.

Conserved Motifs within Hepatitis C Virus Envelope (E2) RNA and Protein Independently Inhibit T Cell Activation.

T cell receptor (TCR) signaling is required for T-cell activation, proliferation, differentiation, and effector function. Hepatitis C virus (HCV) infection is associated with impaired T-cell function leading to persistent viremia, delayed and inconsistent antibody responses, and mild immune dysfunct...

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Bibliographic Details
Main Authors: Nirjal Bhattarai, James H McLinden, Jinhua Xiang, Thomas M Kaufman, Jack T Stapleton
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-09-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4589396?pdf=render

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http://europepmc.org/articles/PMC4589396?pdf=render

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