Intracerebroventricular administration of oxytocin and intranasal administration of the oxytocin derivative improve β‐amyloid peptide (25–35)‐induced memory impairment in mice

Intracerebroventricular administration of oxytocin and intranasal administration of the oxytocin derivative improve β‐amyloid peptide (25–35)‐induced memory impairment in mice

Abstract Aim We previously reported that oxytocin, a peptide hormone, can reverse the β‐amyloid peptide (25–35) (Aβ25–35)‐induced impairments of the murine hippocampal synaptic plasticity. In this study, we examined the effects of oxytocin on the Aβ25–35‐induced impairment of cognitive behavior in m...

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Bibliographic Details
Main Authors: Junpei Takahashi, Yudai Ueta, Daisuke Yamada, Sachie Sasaki‐Hamada, Takashi Iwai, Tomomi Akita, Chikamasa Yamashita, Akiyoshi Saitoh, Jun‐Ichiro Oka
Format: Article
Language:English
Published: Wiley 2022-12-01
Series:Neuropsychopharmacology Reports
Subjects:
amnesia
brain drug delivery and targeting
intranasal administration
oxytocin
spatial memory
β‐amyloid peptide (25–35)
Online Access:https://doi.org/10.1002/npr2.12292

Internet

https://doi.org/10.1002/npr2.12292

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