Impaired synaptic plasticity in an animal model of autism exhibiting early hippocampal GABAergic-BDNF/TrkB signaling alterations

Impaired synaptic plasticity in an animal model of autism exhibiting early hippocampal GABAergic-BDNF/TrkB signaling alterations

Summary: In Neurodevelopmental Disorders, alterations of synaptic plasticity may trigger structural changes in neuronal circuits involved in cognitive functions. This hypothesis was tested in mice carrying the human R451C mutation of Nlgn3 gene (NLG3R451C KI), found in some families with autistic ch...

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Hlavní autoři: Martina Sgritta, Beatrice Vignoli, Domenico Pimpinella, Marilena Griguoli, Spartaco Santi, Andrzej Bialowas, Grzegorz Wiera, Paola Zacchi, Francesca Malerba, Cristina Marchetti, Marco Canossa, Enrico Cherubini
Médium: Článek
Jazyk:English
Vydáno: Elsevier 2023-01-01
Edice:iScience
Témata:
Neuroscience
Developmental neuroscience
Cellular neuroscience
On-line přístup:http://www.sciencedirect.com/science/article/pii/S2589004222020016

Internet

http://www.sciencedirect.com/science/article/pii/S2589004222020016

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