Hexokinase-linked glycolytic overload and unscheduled glycolysis in hyperglycemia-induced pathogenesis of insulin resistance, beta-cell glucotoxicity, and diabetic vascular complications

Hexokinase-linked glycolytic overload and unscheduled glycolysis in hyperglycemia-induced pathogenesis of insulin resistance, beta-cell glucotoxicity, and diabetic vascular complications

Hyperglycemia is a risk factor for the development of insulin resistance, beta-cell glucotoxicity, and vascular complications of diabetes. We propose the hypothesis, hexokinase-linked glycolytic overload and unscheduled glycolysis, in explanation. Hexokinases (HKs) catalyze the first step of glucose...

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Bibliographic Details
Main Authors: Naila Rabbani, Paul J. Thornalley
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Endocrinology
Subjects:
hyperglycermia
glucose metabolism
insulin resistance
glucotoxicity
diabetes
vascular complications
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1268308/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2023.1268308/full

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