Structural Insight into the Two-Step Mechanism of PAI-1 Inhibition by Small Molecule TM5484

Structural Insight into the Two-Step Mechanism of PAI-1 Inhibition by Small Molecule TM5484

Plasminogen activator inhibitor-1 (PAI-1), a key regulator of the fibrinolytic system, is the main physiological inhibitor of plasminogen activators. By interacting with matrix components, including vitronectin (Vn), PAI-1 plays a regulatory role in tissue remodeling, cell migration, and intracellul...

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Bibliographic Details
Main Authors: Machteld Sillen, Toshio Miyata, Douglas E. Vaughan, Sergei V. Strelkov, Paul J. Declerck
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
plasminogen activator inhibitor 1
cardiovascular disease
fibrinolysis
thrombolysis
PAI-1 inhibitor
X-ray crystallography
Online Access:https://www.mdpi.com/1422-0067/22/3/1482

Internet

https://www.mdpi.com/1422-0067/22/3/1482

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