Solid-Phase Synthesis of the Bicyclic Peptide OL-CTOP Containing Two Disulfide Bridges, and an Assessment of Its In Vivo μ-Opioid Receptor Antagonism after Nasal Administration

Solid-Phase Synthesis of the Bicyclic Peptide OL-CTOP Containing Two Disulfide Bridges, and an Assessment of Its In Vivo μ-Opioid Receptor Antagonism after Nasal Administration

New strategies facilitate the design of cyclic peptides which can penetrate the brain. We have designed a bicyclic peptide, OL-CTOP, composed of the sequences of a selective μ-opioid receptor antagonist, CTOP (f-<i>cyclo</i>(CYwOTX)T) (X = penicillamine, Pen; O = ornithine) and odorranal...

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Bibliographic Details
Main Authors: Ramanjaneyulu Rayala, Annika Tiller, Shahayra A. Majumder, Heather M. Stacy, Shainnel O. Eans, Aleksandra Nedovic, Jay P. McLaughlin, Predrag Cudic
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Molecules
Subjects:
intranasal delivery
odorranalectin
CTOP
disulfide bond
solid-phase synthesis
trypsin
Online Access:https://www.mdpi.com/1420-3049/28/4/1822

Internet

https://www.mdpi.com/1420-3049/28/4/1822

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