Profiling of ERBB receptors and downstream pathways reveals selectivity and hidden properties of ERBB4 antagonists

Profiling of ERBB receptors and downstream pathways reveals selectivity and hidden properties of ERBB4 antagonists

Summary: ERBB receptor tyrosine kinases are involved in development and diseases like cancer, cardiovascular, neurodevelopmental, and mental disorders. Although existing drugs target ERBB receptors, the next generation of drugs requires enhanced selectivity and understanding of physiological pathway...

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Bibliographic Details
Main Authors: Lukša Popović, Jan P. Wintgens, Yuxin Wu, Ben Brankatschk, Sascha Menninger, Carsten Degenhart, Niels Jensen, Sven P. Wichert, Bert Klebl, Moritz J. Rossner, Michael C. Wehr
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:iScience
Subjects:
Pharmacology
Natural sciences
Biological sciences
Biochemistry
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224000609

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http://www.sciencedirect.com/science/article/pii/S2589004224000609

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