Structural Insights into <i>Escherichia coli</i> Shiga Toxin (Stx) Glycosphingolipid Receptors of Porcine Renal Epithelial Cells and Inhibition of Stx-Mediated Cellular Injury Using Neoglycolipid-Spiked Glycovesicles

Structural Insights into <i>Escherichia coli</i> Shiga Toxin (Stx) Glycosphingolipid Receptors of Porcine Renal Epithelial Cells and Inhibition of Stx-Mediated Cellular Injury Using Neoglycolipid-Spiked Glycovesicles

Shiga toxin (Stx) producing <i>Escherichia coli</i> (STEC) cause the edema disease in pigs by releasing the swine-pathogenic Stx2e subtype as the key virulence factor. Stx2e targets endothelial cells of animal organs including the kidney harboring the Stx receptor glycosphingolipids (GSL...

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Bibliographic Details
Main Authors: Johanna Detzner, Caroline Gloerfeld, Gottfried Pohlentz, Nadine Legros, Hans-Ulrich Humpf, Alexander Mellmann, Helge Karch, Johannes Müthing
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Microorganisms
Subjects:
edema disease
epithelial cells
gb3cer
gb4cer
glycosphingolipids
llc-pk1
neoglycolipids
pk-15
porcine kidney
stx2e
Online Access:https://www.mdpi.com/2076-2607/7/11/582

Internet

https://www.mdpi.com/2076-2607/7/11/582

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