DNA Base Bioisosteres, Bis-benzoxazoles, Exert Anti-proliferative Effect on Human Prostate and Breast Cancer Cells
A series of symmetric bis-benzoxazole derivatives were synthesized using one-pot cyclisation reaction between 4-chloro substituted 2-aminophenol and suitable dicarboxylic acids. Synthesized compounds’ anticancer activities were tested by using MTT assay on human prostate (DU145) and breast (MCF7) ca...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Turkish Chemical Society
2018-09-01
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| Series: | Journal of the Turkish Chemical Society, Section A: Chemistry |
| Subjects: | |
| Online Access: | http://dergipark.gov.tr/jotcsa/issue/37193/429504 |
| _version_ | 1797905715755483136 |
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| author | Furkan Ayaz Rusmeenee Kheeree Qadar Ahmed Isse Ronak Haj Ersan Oztekin Algul |
| author_facet | Furkan Ayaz Rusmeenee Kheeree Qadar Ahmed Isse Ronak Haj Ersan Oztekin Algul |
| author_sort | Furkan Ayaz |
| collection | DOAJ |
| description | A series of symmetric bis-benzoxazole derivatives were synthesized using one-pot cyclisation reaction between 4-chloro substituted 2-aminophenol and suitable dicarboxylic acids. Synthesized compounds’ anticancer activities were tested by using MTT assay on human prostate (DU145) and breast (MCF7) cancer cells. Screening results revealed that all compounds possessed a high level anti-cancer potential by significantly decreasing the cell proliferation in prostate and breast cancer cell lines. Our compounds exerted their anti-proliferative effects in a dose and time dependent manner. Our results suggest that they can be highly potent since they were biologically active even at low concentrations. Our study presents a series of new bis-benzoxazole based compounds with potential therapeutic effects against tumor cells. Therefore, characterization of new generation bis-benzoxazole derivatives will have a significant contribution on the development of new era anti-cancer drug candidates. |
| first_indexed | 2024-04-10T10:09:38Z |
| format | Article |
| id | doaj.art-ff63c9efd7264ab3a430ee37da4fea5d |
| institution | Directory Open Access Journal |
| issn | 2149-0120 |
| language | English |
| last_indexed | 2024-04-10T10:09:38Z |
| publishDate | 2018-09-01 |
| publisher | Turkish Chemical Society |
| record_format | Article |
| series | Journal of the Turkish Chemical Society, Section A: Chemistry |
| spelling | doaj.art-ff63c9efd7264ab3a430ee37da4fea5d2023-02-15T16:22:17ZengTurkish Chemical SocietyJournal of the Turkish Chemical Society, Section A: Chemistry2149-01202018-09-01531145115210.18596/jotcsa.429504DNA Base Bioisosteres, Bis-benzoxazoles, Exert Anti-proliferative Effect on Human Prostate and Breast Cancer CellsFurkan Ayaz0Rusmeenee Kheeree1Qadar Ahmed Isse2Ronak Haj Ersan3Oztekin Algul4Mersin University, Biotechnology Department, (33110 ), (Mersin), (Turkey )Mersin University, Biotechnology Department, (33110 ), (Mersin), (Turkey )Mersin University, Biotechnology Department, (33110 ), (Mersin), (Turkey )Mersin University, Faculty of Pharmacy, Department of P harmaceutical C hemistry, (33169 ), (Mersin), (Turkey)Mersin University, Faculty of Pharmacy, Department of P harmaceutical C hemistry, (33169 ), (Mersin), (Turkey)A series of symmetric bis-benzoxazole derivatives were synthesized using one-pot cyclisation reaction between 4-chloro substituted 2-aminophenol and suitable dicarboxylic acids. Synthesized compounds’ anticancer activities were tested by using MTT assay on human prostate (DU145) and breast (MCF7) cancer cells. Screening results revealed that all compounds possessed a high level anti-cancer potential by significantly decreasing the cell proliferation in prostate and breast cancer cell lines. Our compounds exerted their anti-proliferative effects in a dose and time dependent manner. Our results suggest that they can be highly potent since they were biologically active even at low concentrations. Our study presents a series of new bis-benzoxazole based compounds with potential therapeutic effects against tumor cells. Therefore, characterization of new generation bis-benzoxazole derivatives will have a significant contribution on the development of new era anti-cancer drug candidates.http://dergipark.gov.tr/jotcsa/issue/37193/429504Bis-benzoxazolebreast cancerprostate canceranti-proliferativeanti-cancerMTT |
| spellingShingle | Furkan Ayaz Rusmeenee Kheeree Qadar Ahmed Isse Ronak Haj Ersan Oztekin Algul DNA Base Bioisosteres, Bis-benzoxazoles, Exert Anti-proliferative Effect on Human Prostate and Breast Cancer Cells Journal of the Turkish Chemical Society, Section A: Chemistry Bis-benzoxazole breast cancer prostate cancer anti-proliferative anti-cancer MTT |
| title | DNA Base Bioisosteres, Bis-benzoxazoles, Exert Anti-proliferative Effect on Human Prostate and Breast Cancer Cells |
| title_full | DNA Base Bioisosteres, Bis-benzoxazoles, Exert Anti-proliferative Effect on Human Prostate and Breast Cancer Cells |
| title_fullStr | DNA Base Bioisosteres, Bis-benzoxazoles, Exert Anti-proliferative Effect on Human Prostate and Breast Cancer Cells |
| title_full_unstemmed | DNA Base Bioisosteres, Bis-benzoxazoles, Exert Anti-proliferative Effect on Human Prostate and Breast Cancer Cells |
| title_short | DNA Base Bioisosteres, Bis-benzoxazoles, Exert Anti-proliferative Effect on Human Prostate and Breast Cancer Cells |
| title_sort | dna base bioisosteres bis benzoxazoles exert anti proliferative effect on human prostate and breast cancer cells |
| topic | Bis-benzoxazole breast cancer prostate cancer anti-proliferative anti-cancer MTT |
| url | http://dergipark.gov.tr/jotcsa/issue/37193/429504 |
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