Challenges and Strategies for Developing Recombinant Vaccines against Leptospirosis: Role of Expression Platforms and Adjuvants in Achieving Protective Efficacy

Challenges and Strategies for Developing Recombinant Vaccines against Leptospirosis: Role of Expression Platforms and Adjuvants in Achieving Protective Efficacy

The first leptospiral recombinant vaccine was developed in the late 1990s. Since then, progress in the fields of reverse vaccinology (RV) and structural vaccinology (SV) has significantly improved the identification of novel surface-exposed and conserved vaccine targets. However, developing recombin...

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Bibliographic Details
Main Authors: Natasha Rodrigues de Oliveira, Francisco Denis Souza Santos, Vitória Adrielly Catschor dos Santos, Mara Andrade Colares Maia, Thaís Larré Oliveira, Odir Antônio Dellagostin
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Pathogens
Subjects:
vaccine development
<i>Leptospira</i>
recombinant DNA technology
adjuvants
hamster model
Online Access:https://www.mdpi.com/2076-0817/12/6/787

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https://www.mdpi.com/2076-0817/12/6/787

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