TRIM46 aggravated high glucose-induced hyper permeability and inflammatory response in human retinal capillary endothelial cells by promoting IκBα ubiquitination

TRIM46 aggravated high glucose-induced hyper permeability and inflammatory response in human retinal capillary endothelial cells by promoting IκBα ubiquitination

Abstract Background Diabetic retinopathy (DR) as a severe diabetic complication contributes to blindness. The increased permeability of retinal capillary endothelial cells (RCECs) as well as the production of inflammatory markers are closely related to DR occurrence. We recently revealed that TRIM46...

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Bibliographic Details
Main Authors: Hangqi Shen, Qiaoyun Gong, Jingting Zhang, Haiyan Wang, Qinghua Qiu, Jingfa Zhang, Dawei Luo
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Eye and Vision
Subjects:
Diabetic retinopathy
TRIM46
IκBα
Ubiquitination
NF-κB
Online Access:https://doi.org/10.1186/s40662-022-00305-2

Internet

https://doi.org/10.1186/s40662-022-00305-2

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